Tees Maar Khan revolves around conman Tabrez Mirza Khan (TMK, Akshay Kumar) who has been a criminal since he was young. He was caught in France and was deported back to India. Two police officers Chatterjee (Aman Verma) and Mukherjee (Murli Sharma) took him but he escaped.
He is in love with the struggling actress Anya (Katrina Kaif). TMK takes a job from the Johri brothers to rob a non-stop train loaded with precious antiques. He cons the people of Dhulia village into helping him by saying that he will make a historical film about their village. He approaches the greedy but popular actor Aatish Kapoor (Akshaye Khanna), who is eager to get the Oscar award and fools him into working in his film. The robbery goes well but all the villagers and Tabrez Mirza Khan get arrested. TMK claims that he is innocent, but he gets arrested anyway. Whether TMK gets free or pays for his crimes is the crux of the film