Kirron Kher’s first marriage was with actor and businessman Gautam Berry, whom she divorced in 1985. She then married actor Anupam Kher. Her son Sikander was legally adopted by Anupam after marriage.In 1988, she made Kirron Kher debut in the film Pestonjee.In 1995, she worked for husband Anupam Kher as a costume designer and suggested the title for his movie Dilwale Dulhania Le Jayenge.In 1999, Kirron Kher won the National Award For Best Actress for the Bengali film Bariwali.In 2003, she was nominated for the Filmfare Best Supporting Actress Award for Devdas. Kirron Kher has hosted three television shows called Purushkshetra, Kirron Kher Today and Jaagte Raho.In 2003, Kher received the Bronze Leopard for her role in Khamosh Pani: Silent Waters at the Locarno International Film Festival.In October 2004, Kirron Kher had a guest appearance along with her husband in the American TV series ER playing Parminder Nagra's mother.In 2006, Kirron Kher's work in Rang De Basanti (2006) was a huge hit and her performance was praised.
Currently she is judging the 7th season of India's got talent along with Malaika Arora Khan and Karan Johar.